Professor Conroy and Buzz unveil the blueprints for the Spy Detector XK-00-7 at a Maximum Security Building. Unfortunately, the blueprints are targeted by the Spyder Man.
Aquator has stolen a secret formula from a scientist who is friends with Big D and shrinks himself to microscopic size in order to get all the microscopic creatures to become large.
Plant Man thaws the last three prehistoric plants (the Carnivorous Chewer, the Creeping Crusher and the Fire-Breathing Snapdragon) from a glacier and then sprays them with his Obedience Ray in a plot to eliminate Buzz and Frankenstein Jr.
Sertano the Satellite King, an alien from Galaxy X, uses a gravity ray in order to get Earth to surrender. Buzz and Frankenstein Jr. must defeat Sertano's robots in order to defeat him.
To perform a crime wave in London, Baron Von Ghoul creates robotic versions of the horror movie monsters the Electroflying Firefly, the Menacing Mummy, and the Wicked Werewolf.
Mr. Menace uses his putty monster to steal a $1,000,000 coin collection and even kidnaps Buzz. It is up to Frankenstein Jr. to rescue Buzz and defeat Mr. Menace.